We currently have a specialty tissue collection of both breast and prostate cancer matched with clinical data and MRI, mammography, and ultrasound data. This collection was specifically for the identification of imaging phenotypes and classifiers in correlation with tumor genotypes for characterization of breast and prostate cancer. This is a unique collection of tissue and data that may be of interest to your clients. Please inquire.

TMAs are created from biological materials and are such are subject to variability.  For example, in tumor tissues, the amount of intervening stroma, necrosis or surrounding inflammatory reaction is highly variable.  While the small size of the samples makes microarrays a powerful screening tool, the small tissue samples may not always be representative of the the entire tumor, due to the intratumor heterogeneity characteristic of most tumors.  Thus, the prevalence of a molecular alteration in a specimen microarray may be underestimated.  Sampling bias may not be a serious concern if the tumor areas are carefully selected for punching.  This sometimes warrants collection of multiple samples from different sites of the same tumor in an attempt to obtain accurate sampling from histologically representative regions.  Therefore, it is possible that some representations may be missing on particular microarray slides.  For this reason, we take the time to construct our arrays to ensure a sufficient number of informative samples on every section.

Specimen microarrays are compiled using specimens collected in compliance with Human Subject Certification regulations, including patient consent and IRB (Institutional Review Board) Approval.